Toxic epidermal necrolysis
(Redirected from Toxic Epidermal Necrolysis)
Toxic epidermal necrolysis is a severe rash in which the outer layers of skin blister and peel off.
Skin reaction[edit | edit source]
- Toxic epidermal necrolysis (TEN) is a type of severe skin reaction.
- Together with Stevens-johnson syndrome (SJS) it forms a spectrum of disease, with TEN being more severe.
Symptoms[edit | edit source]
- Early symptoms include fever and flu-like symptoms.
- A few days later the skin begins to blister and peel forming painful raw areas.
- Mucous membranes, such as the mouth, are also typically involved.
Treatment[edit | edit source]
- Treatment needs should be assessed in the hospital to determine severity and where treatment should be provided (e.g. intensive care unit, burn unit, or dermatology unit).
- Treatment may involve stopping a triggering medication (for those suspected of having medication-induced SJS/TEN), standard therapies used for major burns, various eye treatments (for those with eye involvement), pain control, and preventing and treating infections.
Mortality[edit | edit source]
The overall mortality rate is about 25%, ranging from about 10% for SJS to over 30% for TEN.
Cause of death[edit | edit source]
The most common causes of death include sepsis, acute respiratory distress syndrome, and multiple organ failure.
Complications[edit | edit source]
- Those that survive may experience recurrence (particularly if re-exposed to a trigger) and/or long-term complications involving the skin and affected mucous membranes.
- Complications include dehydration, sepsis, pneumonia, and multiple organ failure.
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