Triamcinolone acetonide

Triamcinolone_acetonide.svg

Triamcinolone acetonide.svg

Triamcinolone acetonide is a synthetic corticosteroid used to treat various skin conditions, reduce inflammation, and suppress the immune system. It is commonly marketed under brand names such as Kenalog and Nasacort.

Medical uses

Triamcinolone acetonide is used in the treatment of several conditions, including:

• Eczema
• Psoriasis
• Allergic rhinitis
• Arthritis
• Lupus erythematosus

It is available in various forms, including topical creams, ointments, nasal sprays, and injectable solutions.

Mechanism of action

Triamcinolone acetonide works by inhibiting the release of substances in the body that cause inflammation. It binds to glucocorticoid receptors, leading to a decrease in the production of inflammatory mediators such as prostaglandins and leukotrienes.

Side effects

Common side effects of triamcinolone acetonide include:

• Skin irritation
• Dryness
• Redness
• Burning sensation

Long-term use can lead to more serious side effects such as:

• Skin atrophy
• Hyperglycemia
• Osteoporosis
• Cushing's syndrome

Pharmacokinetics

Triamcinolone acetonide is metabolized in the liver and excreted primarily through the kidneys. The elimination half-life varies depending on the route of administration.

Contraindications

Triamcinolone acetonide should not be used in individuals with:

• Systemic fungal infections
• Known hypersensitivity to the drug

See also

• Corticosteroid
• Inflammation
• Immune system

References

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