(Leu15

. Gastrin-17]]

Synonyms

(Leu15]. Gastrin-17, GAST 17, GAST-17, GAST17

Thesaurus

A C-terminal amidated synthetic gastrin analog with a single amino acid change at position 15, where leucine replaces methionine, with potential hypoglycemic and immunomodulatory activities. Following pancreatic islet cell transplantation, subcutaneous administration of (Leu15]. Gastrin-17 (GAST-17) may induce pancreatic beta cell regeneration and expansion and enhance the insulin secretory capacity of islet cell grafts. Additionally, GAST-17 may reduce inflammation within the islet cell environment, which could potentially improve islet graft survival and function. Gastrin, a gastrointestinal peptide, may induce beta cell neogenesis via induction of the duodenal and pancreatic homeobox transcription factor, PDX-1. Gastrin may also promote beta cell proliferation and neogenesis indirectly through increasing the production of clustrin, a beta cell expansion factor. (Leu15]. Gastrin-17, Pharmacologic Substance

• NCI Thesaurus (external) C548.

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