(Leu15]. Gastrin-17, GAST 17, GAST-17, GAST17
A C-terminal amidated synthetic gastrin analog with a single amino acid change at position 15, where leucine replaces methionine, with potential hypoglycemic and immunomodulatory activities. Following pancreatic islet cell transplantation, subcutaneous administration of (Leu15]. Gastrin-17 (GAST-17) may induce pancreatic beta cell regeneration and expansion and enhance the insulin secretory capacity of islet cell grafts. Additionally, GAST-17 may reduce inflammation within the islet cell environment, which could potentially improve islet graft survival and function. Gastrin, a gastrointestinal peptide, may induce beta cell neogenesis via induction of the duodenal and pancreatic homeobox transcription factor, PDX-1. Gastrin may also promote beta cell proliferation and neogenesis indirectly through increasing the production of clustrin, a beta cell expansion factor. (Leu15]. Gastrin-17, Pharmacologic Substance
- NCI Thesaurus (external) C548.
(Leu15 - AI prompts and tools
- As a Professor: - Act as a professor, expand and write a detailed article on (Leu15.
- Encyclopedia Entry: - Generate a comprehensive encyclopedia article on the topic of (Leu15.
- Subject Matter Expertise: - Expand and refine the content provided to create a professional article on (Leu15 with references.
Note:Feel free to use AI tools to expand this topic using the text on the page followed by the prompt.
|stub. Help WikiMD grow by registering to expand it.|