1,4-dihydroxy-2-naphthoate polyprenyltransferase

Brief summary - 1,4-dihydroxy-2-naphthoate polyprenyltransferase

1-4-dihydroxy-2-napthoate (DHNA) polyprenyltransferase (EC 2.5.1.74) is an enzyme that catalyzes the chemical reaction: all-trans-nonaprenyl diphosphate + 1-4-dihydroxy-2-napthoate + H+ demethylmenaquinol-9 + diphosphate + carbon dioxide Hence, the 3 substrates of this enzyme are all-trans-nonaprenyl diphosphate, 1-4-dihydroxy-2-napthoate, and a hydrogen ion, and the three products are demethylmenaquinol-9, diphosphate, and carbon dioxide. However, other substrates this enzyme can use include farnesyl diphosphate or solanesyl diphosphate in replacement of all-trans-nonaprenyl diphosphate
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