AANAT (gene)

AANAT (Arylalkylamine N-acetyltransferase) is a gene that encodes the enzyme arylalkylamine N-acetyltransferase. This enzyme is significant in the biological rhythms of mammals, as it plays a crucial role in the melatonin synthesis pathway.

Function

The AANAT gene is responsible for the production of the enzyme arylalkylamine N-acetyltransferase. This enzyme is involved in the daily rhythms of hormone secretion and behavior by catalyzing the transfer of an acetyl group from acetyl coenzyme A to arylalkylamines, such as serotonin. The acetylation of serotonin is the first step in the synthesis of melatonin, a hormone that regulates sleep-wake cycles and other circadian rhythms.

Clinical significance

Mutations in the AANAT gene have been associated with a variety of disorders, including seasonal affective disorder, insomnia, and certain types of cancer. Research is ongoing to further understand the role of this gene in these and other conditions.

See also

• Melatonin
• Circadian rhythm
• Gene
• Enzyme