Anti-amyloid drugs
Anti-amyloid drugs are a class of pharmacological agents used in the treatment of diseases characterized by the accumulation of amyloid proteins in various organs and tissues. These diseases, collectively known as Amyloidosis, can be systemic or localized, and are often progressive and life-threatening.
Mechanism of Action[edit | edit source]
Anti-amyloid drugs work by inhibiting the formation of amyloid fibrils, promoting the clearance of existing fibrils, or stabilizing the precursor proteins to prevent their misfolding and aggregation. The exact mechanism of action varies depending on the specific drug and the type of amyloidosis being treated.
Types of Anti-amyloid Drugs[edit | edit source]
There are several types of anti-amyloid drugs, each targeting a specific type of amyloid protein. These include:
- Tafamidis: A transthyretin stabilizer used in the treatment of transthyretin amyloid cardiomyopathy and transthyretin familial amyloid polyneuropathy.
- Doxycycline and Tauroursodeoxycholic acid (TUDCA): Used in combination for the treatment of AL amyloidosis.
- Patisiran and Inotersen: RNA interference drugs used in the treatment of hereditary transthyretin-mediated amyloidosis.
Clinical Use[edit | edit source]
The use of anti-amyloid drugs is typically reserved for patients with confirmed diagnosis of amyloidosis. The choice of drug depends on the type of amyloidosis, the specific organ systems involved, and the patient's overall health status.
Side Effects[edit | edit source]
Like all drugs, anti-amyloid drugs can have side effects. These can include gastrointestinal symptoms, infusion reactions, and liver toxicity. Regular monitoring is required to manage these potential side effects.
Research and Development[edit | edit source]
Research into new anti-amyloid drugs is ongoing, with several promising candidates in various stages of clinical trials. These include drugs targeting beta-amyloid in Alzheimer's disease, as well as drugs for other types of amyloidosis.
See Also[edit | edit source]
- Amyloidosis
- Pharmacology
- Transthyretin amyloid cardiomyopathy
- Transthyretin familial amyloid polyneuropathy
- AL amyloidosis
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
