BD1031

BD1031 or (R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor agonist. It has a reported binding affinity of Ki = 1 ± 0.2 nM for the sigma-1 receptor and exhibits 80 times selectivity over the sigma-2 receptor.

Pharmacology

BD1031 is a potent and selective agonist for the sigma-1 receptor. The sigma-1 receptor is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. In the context of neurobiology, sigma-1 receptor agonists have been shown to promote neuroplasticity and cell survival, and are being investigated for their potential therapeutic use in the treatment of neurodegenerative diseases.

BD1031 has a high binding affinity for the sigma-1 receptor, with a reported Ki value of 1 ± 0.2 nM. This means that it binds to the sigma-1 receptor with high potency, potentially leading to a strong agonist effect.

In addition to its high affinity for the sigma-1 receptor, BD1031 also exhibits selectivity for the sigma-1 receptor over the sigma-2 receptor. It is reported to be 80 times more selective for the sigma-1 receptor than the sigma-2 receptor. This selectivity could make BD1031 a useful tool in research and potentially in the development of therapeutics that target the sigma-1 receptor.

Potential Therapeutic Uses

Given its potent and selective agonist activity at the sigma-1 receptor, BD1031 is of interest for its potential therapeutic uses. Sigma-1 receptor agonists have been shown to promote neuroplasticity and cell survival, suggesting potential applications in the treatment of neurodegenerative diseases.

However, further research is needed to fully understand the potential therapeutic applications of BD1031 and other sigma-1 receptor agonists.

See Also

• Sigma receptor
• Sigma-1 receptor
• Sigma-2 receptor
• Neuroplasticity
• Neurodegenerative diseases

BD1031 Resources
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