CUMYL-5F-PICA
CUMYL-5F-PICA_structure.png | |
CUMYL-5F-PICA is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the cannabinoid receptors, specifically the CB1 and CB2 receptors, which are part of the endocannabinoid system.
Chemical Structure and Properties[edit | edit source]
CUMYL-5F-PICA belongs to the indole-3-carboxamide family of synthetic cannabinoids. Its chemical structure is characterized by a 5-fluoropentyl chain attached to the indole core, with an isopropylphenyl group at the nitrogen atom of the indole. The presence of the fluorine atom in the pentyl chain is a common modification in synthetic cannabinoids, which often increases their potency and metabolic stability.
Pharmacology[edit | edit source]
CUMYL-5F-PICA acts as a full agonist at the CB1 and CB2 receptors. These receptors are G-protein coupled receptors that mediate the effects of endogenous cannabinoids like anandamide and 2-arachidonoylglycerol. Activation of these receptors by CUMYL-5F-PICA can lead to a range of effects, including psychoactive effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Effects and Toxicity[edit | edit source]
The effects of CUMYL-5F-PICA are similar to those of other synthetic cannabinoids, which can include euphoria, altered perception, and relaxation. However, synthetic cannabinoids are often associated with severe adverse effects, including tachycardia, hypertension, nausea, vomiting, anxiety, paranoia, and hallucinations. There have been reports of severe toxicity and fatalities associated with the use of synthetic cannabinoids, including CUMYL-5F-PICA.
Legal Status[edit | edit source]
CUMYL-5F-PICA is illegal in several countries due to its potential for abuse and lack of medical use. It is often included in legislation that bans synthetic cannabinoids as a class. In the United States, it may be considered a Schedule I substance under the Controlled Substances Act if it is deemed to be an analogue of a controlled substance.
Synthesis and Detection[edit | edit source]
The synthesis of CUMYL-5F-PICA involves the reaction of 5-fluoropentylindole with an isopropylphenyl isocyanate. Detection of CUMYL-5F-PICA in biological samples can be challenging due to its structural similarity to other synthetic cannabinoids. Advanced analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) are often required for its identification.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD