Cortistatin-8

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Cortistatin-8

Cortistatin-8 is a synthetic peptide that acts as an antagonist of the cortistatin receptor. It is primarily used in research to study the physiological and pharmacological roles of cortistatin, a neuropeptide that shares structural similarities with somatostatin but has distinct biological functions.

Structure and Function[edit | edit source]

Cortistatin-8 is a modified peptide designed to selectively block the actions of cortistatin. Cortistatin itself is a cyclic neuropeptide that is encoded by the CORT gene in humans. It is known to interact with somatostatin receptors, particularly the SSTR2, but also has unique effects that are not shared by somatostatin.

Cortistatin-8 is used to differentiate the effects of cortistatin from those of somatostatin by selectively inhibiting cortistatin's action without affecting somatostatin. This makes it a valuable tool in neuroendocrinology and neuropharmacology research.

Biological Role of Cortistatin[edit | edit source]

Cortistatin is involved in a variety of physiological processes, including:

  • Sleep Regulation: Cortistatin has been shown to promote slow-wave sleep, similar to somatostatin, but with additional effects on sleep architecture.
  • Immune System Modulation: It has immunomodulatory effects, influencing the activity of immune cells and the production of cytokines.
  • Neurotransmission: Cortistatin modulates neurotransmitter release and has been implicated in the regulation of neuronal excitability.
  • Cardiovascular Effects: It can influence cardiovascular function, including blood pressure regulation.

Research Applications[edit | edit source]

Cortistatin-8 is used in experimental settings to:

  • Dissect Cortistatin Pathways: By blocking cortistatin, researchers can study its specific pathways and distinguish them from those of somatostatin.
  • Investigate Sleep Disorders: Understanding cortistatin's role in sleep can lead to new insights into sleep disorders and potential therapeutic targets.
  • Explore Immune Function: The peptide is used to study cortistatin's effects on the immune system, which may have implications for autoimmune diseases and inflammation.

Synthesis and Availability[edit | edit source]

Cortistatin-8 is synthesized using standard peptide synthesis techniques. It is commercially available from various biochemical suppliers for research purposes.

Safety and Handling[edit | edit source]

As with all research chemicals, cortistatin-8 should be handled with care. Appropriate safety measures, including the use of personal protective equipment and adherence to institutional guidelines, should be followed.

Also see[edit | edit source]



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