DR3

DR3 (Death receptor 3) is a protein that in humans is encoded by the DR3 gene. It is also known as APO-3, LARD, TRAMP, and WSL-1. DR3 is a member of the tumor necrosis factor receptor superfamily. This receptor is expressed in tissues such as lymphoid tissue and activated T cells and B cells. It has been shown to stimulate NF-kappa B activity and regulate cell apoptosis.

Function

The protein encoded by the DR3 gene is a death domain containing receptor and has been shown to play a central role in the physiological regulation of programmed cell death. The encoded protein is found on the cell surface and interacts with ligands to induce apoptosis. It contains an extracellular domain, a transmembrane domain, and a cytoplasmic death domain. This protein is involved in the TNF-mediated apoptosis pathway.

Clinical significance

Mutations in the DR3 gene have been associated with various diseases, including autoimmune lymphoproliferative syndrome (ALPS), a rare inherited disorder of the immune system, and non-Hodgkin's lymphoma. The DR3 gene is also involved in susceptibility to multiple sclerosis and asthma.

Interactions

DR3 has been shown to interact with TRADD and FADD.

See also

• Death receptor
• Tumor necrosis factor receptor
• Autoimmune lymphoproliferative syndrome
• Multiple sclerosis
• Asthma

External links

• DR3 at the US National Library of Medicine Medical Subject Headings (MeSH)

DR3 Resources
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