EDIL3

EDIL3 (EGF-like repeats and discoidin I-like domains 3) is a protein that in humans is encoded by the EDIL3 gene. It is a member of the EGF repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes.

Function

EDIL3 is an extracellular matrix protein that promotes endothelial cell adhesion and angiogenesis. It also plays a role in cell migration and tissue repair. EDIL3 is known to interact with integrins and other extracellular matrix proteins, facilitating cell-cell and cell-matrix interactions.

Clinical significance

Alterations in the expression of EDIL3 have been associated with various pathological conditions, including cancer, cardiovascular diseases, and inflammatory diseases. In cancer, overexpression of EDIL3 has been observed in several types of tumors and is associated with poor prognosis. In cardiovascular diseases, EDIL3 has been implicated in the regulation of angiogenesis, a process that is critical for the growth and development of new blood vessels. In inflammatory diseases, EDIL3 has been shown to modulate the inflammatory response, suggesting a potential role in the pathogenesis of these conditions.

Research

Research is ongoing to further understand the role of EDIL3 in health and disease. This includes studies to elucidate the molecular mechanisms underlying EDIL3 function and to explore the potential of EDIL3 as a therapeutic target in various diseases.

See also

• EGF
• Extracellular matrix
• Angiogenesis
• Integrin