JNJ-26993135

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JNJ-26993135

Drug Information
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Identifiers ATC Code DrugBank ChEBI		Chemical Data O

JNJ-26993135 is a chemical compound that has been investigated for its potential use as a pharmaceutical drug. It is primarily known for its action as a serotonin receptor antagonist, specifically targeting the 5-HT2A receptor.

Pharmacology

JNJ-26993135 acts as a selective antagonist at the 5-HT2A receptor, which is a subtype of the serotonin receptor family. The 5-HT2A receptor is involved in various neurological processes, including mood regulation, perception, and cognition. By blocking this receptor, JNJ-26993135 may have potential therapeutic effects in conditions such as schizophrenia, depression, and anxiety disorders.

Research and Development

JNJ-26993135 was developed by Johnson & Johnson as part of their research into novel treatments for psychiatric disorders. Preclinical studies have shown that JNJ-26993135 can modulate neurotransmitter systems in the brain, leading to potential antipsychotic and antidepressant effects. However, as of the latest updates, JNJ-26993135 has not been approved for clinical use and remains an investigational compound.

Mechanism of Action

The primary mechanism of action of JNJ-26993135 is its antagonism of the 5-HT2A receptor. This receptor is a G protein-coupled receptor that, when activated by serotonin, can influence various downstream signaling pathways. By inhibiting this receptor, JNJ-26993135 may alter the balance of neurotransmitter activity in the brain, which could be beneficial in treating disorders characterized by dysregulated serotonin signaling.

Potential Clinical Applications

While JNJ-26993135 is not currently approved for any clinical applications, its pharmacological profile suggests potential use in:

• Schizophrenia: As an antipsychotic agent due to its ability to modulate serotonin pathways.
• Depression: As an adjunctive treatment to enhance the effects of traditional antidepressants.
• Anxiety disorders: By reducing overactivity in serotonin pathways that may contribute to anxiety symptoms.

Safety and Efficacy

The safety and efficacy of JNJ-26993135 have been evaluated in preclinical studies, but comprehensive clinical trials are necessary to determine its potential as a therapeutic agent. As with any investigational drug, further research is needed to fully understand its pharmacokinetics, optimal dosing, and long-term effects.

Also see

• Serotonin receptor antagonists
• 5-HT2A receptor
• Antipsychotic drugs
• Johnson & Johnson