JWH-050
| JWH-050_structure.png Chemical structure of JWH-050 | |
JWH-050 is a synthetic cannabinoid that acts as a potent agonist at the CB1 and CB2 receptors. It is part of the naphthoylindole family of compounds and was first synthesized by John W. Huffman in the 1990s as part of research into the structure-activity relationships of cannabinoids.
Chemical Structure and Properties[edit | edit source]
JWH-050 has the chemical formula C₄H₂₃NO and a molecular weight of 341.44 g/mol. The structure consists of a naphthoyl group attached to an indole core, which is a common feature among synthetic cannabinoids. The presence of the naphthoyl group is crucial for its activity at cannabinoid receptors.
Pharmacology[edit | edit source]
JWH-050 is a full agonist at both CB1 and CB2 receptors, with a higher affinity for CB1. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by JWH-050 can lead to effects such as euphoria, altered perception, and relaxation, similar to those produced by tetrahydrocannabinol (THC), the active component of cannabis.
Legal Status[edit | edit source]
The legal status of JWH-050 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In others, it remains legal but may be subject to regulation under analog laws.
Potential Risks and Side Effects[edit | edit source]
The use of JWH-050, like other synthetic cannabinoids, can pose significant health risks. These may include tachycardia, hypertension, anxiety, paranoia, and in severe cases, psychosis. The lack of regulation and quality control in the production of synthetic cannabinoids increases the risk of contamination and unpredictable effects.
Research and Applications[edit | edit source]
JWH-050 has been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, its use is limited due to its potential for abuse and the availability of safer alternatives.
Also see[edit | edit source]
- Synthetic cannabinoids
- Cannabinoid receptor
- John W. Huffman
- Tetrahydrocannabinol
- Endocannabinoid system
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