JWH-151
JWH-151 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.
Chemical Structure and Properties[edit | edit source]
JWH-151 is chemically classified as a naphthoylindole, with the IUPAC name (1-pentylindol-3-yl)-(2-methoxyphenyl)methanone. The compound has a molecular formula of C21H23NO2 and a molar mass of 321.41 g/mol. The structure consists of a pentyl chain attached to the indole core, which is linked to a methoxyphenyl group via a ketone bridge.
Pharmacology[edit | edit source]
JWH-151 is a full agonist at the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor selectivity is similar to that of other compounds in the JWH series, such as JWH-018 and JWH-073. The activation of these receptors by JWH-151 leads to a range of effects, including analgesia, anti-inflammatory effects, and psychoactive effects.
Research and Applications[edit | edit source]
JWH-151, like other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and its role in various physiological processes. Studies have explored its potential therapeutic applications, including pain management and the treatment of inflammatory conditions. However, due to its potent psychoactive effects, JWH-151 is not approved for medical use in humans.
Legal Status[edit | edit source]
The legal status of JWH-151 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Researchers must obtain special licenses to study this compound legally.
Safety and Toxicology[edit | edit source]
The safety profile of JWH-151 is not well-established, as it has not been extensively studied in humans. However, synthetic cannabinoids are known to have a range of adverse effects, including anxiety, paranoia, tachycardia, and in severe cases, psychosis. The long-term effects of JWH-151 use are unknown, and caution is advised when handling this compound in a research setting.
Also see[edit | edit source]
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