SB-218,795
SB-218,795 is a chemical compound that acts as a selective antagonist for the neuropeptide Y receptor Y1. It has been used in scientific research to investigate the role of neuropeptide Y (NPY) in various physiological and pathological processes.
Chemical Structure and Properties[edit | edit source]
SB-218,795 is a synthetic compound with the following chemical structure:
- IUPAC name: (2S)-N-[(1S)-1-[[2-(4-chlorophenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]-2-(2,6-dimethylphenyl)propanamide
- Molecular formula: C26H35ClN2O2
- Molecular weight: 442.02 g/mol
The compound is characterized by its selective binding affinity to the Y1 receptor subtype, which is one of the several receptor subtypes for neuropeptide Y.
Pharmacological Action[edit | edit source]
SB-218,795 functions as a selective antagonist of the neuropeptide Y receptor Y1. Neuropeptide Y is a 36-amino acid peptide neurotransmitter found in the brain and autonomic nervous system. It is involved in various physiological processes, including regulation of energy balance, memory and learning, and modulation of anxiety and stress responses.
By blocking the Y1 receptor, SB-218,795 can inhibit the effects of neuropeptide Y that are mediated through this receptor subtype. This has made it a valuable tool in research studies aimed at understanding the specific roles of Y1 receptor signaling in different biological contexts.
Research Applications[edit | edit source]
SB-218,795 has been utilized in a variety of research studies, including:
- Obesity and Metabolic Disorders: Investigating the role of NPY Y1 receptors in the regulation of appetite and energy homeostasis.
- Anxiety and Depression: Exploring the involvement of Y1 receptors in the modulation of emotional and stress-related behaviors.
- Cardiovascular Studies: Examining the effects of Y1 receptor antagonism on blood pressure and heart rate regulation.
Safety and Toxicology[edit | edit source]
As with many research chemicals, the safety profile of SB-218,795 is not fully established for human use. It is primarily used in laboratory settings under controlled conditions. Researchers handling this compound should follow appropriate safety protocols to minimize exposure and potential risks.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
