SB-222,200

SB-222,200 is a chemical compound that acts as a selective antagonist for the neuropeptide Y receptor Y1. It is primarily used in scientific research to study the physiological and pathological roles of neuropeptide Y (NPY) in the body.

Pharmacology

SB-222,200 is known for its high affinity and selectivity towards the Y1 receptor, one of the five known subtypes of neuropeptide Y receptors. By blocking the Y1 receptor, SB-222,200 helps researchers understand the specific functions of this receptor subtype in various biological processes.

Mechanism of Action

The compound works by binding to the Y1 receptor, thereby inhibiting the action of neuropeptide Y. This inhibition allows researchers to observe changes in physiological responses, which can include alterations in appetite, anxiety, and cardiovascular function, among others.

Research Applications

SB-222,200 is used extensively in preclinical studies to explore the role of the Y1 receptor in:

• Appetite regulation: NPY is a potent stimulator of food intake, and the Y1 receptor is one of the key mediators of this effect.
• Anxiety and stress: The Y1 receptor is involved in the modulation of anxiety and stress responses.
• Cardiovascular system: NPY and its receptors, including Y1, play a role in regulating blood pressure and heart rate.

Chemical Properties

SB-222,200 is a small molecule with a specific chemical structure that allows it to selectively bind to the Y1 receptor. The exact chemical formula and molecular weight are crucial for its function and selectivity.

Safety and Handling

As with many research chemicals, SB-222,200 should be handled with care in a laboratory setting. Proper safety protocols, including the use of personal protective equipment, should be followed to prevent exposure.

Also see

• Neuropeptide Y
• Y1 receptor
• Receptor antagonist
• Pharmacology

Receptor Antagonists
Receptor Type	Example Antagonists
Adrenergic receptor	Propranolol, Prazosin
Cholinergic receptor	Atropine, Scopolamine
Dopamine receptor	Haloperidol, Clozapine
Histamine receptor	Ranitidine, Diphenhydramine
Serotonin receptor	Ondansetron, Risperidone
Glutamate receptor	Memantine, Ketamine
GABA receptor	Flumazenil, Bicuculline
Opioid receptor	Naloxone, Naltrexone
Angiotensin receptor	Losartan, Valsartan