SIN-1A

SIN-1A (3-Morpholinosydnonimine) is a chemical compound that is widely used in biochemical research as a donor of nitric oxide (NO). It is a derivative of sydnonimine and is known for its ability to release NO under physiological conditions, making it a valuable tool for studying the effects of nitric oxide in biological systems.

Chemical Properties

SIN-1A is a sydnonimine compound with the chemical formula C₆H₁₀N₄O₃. It is a white to off-white crystalline powder that is soluble in water. The compound is stable under normal conditions but decomposes to release nitric oxide when exposed to physiological conditions.

Mechanism of Action

SIN-1A acts as a nitric oxide donor. In biological systems, it undergoes a series of chemical reactions that result in the release of NO. This process involves the conversion of SIN-1A to SIN-1, which then decomposes to produce NO and superoxide. The simultaneous release of NO and superoxide can lead to the formation of peroxynitrite, a reactive nitrogen species.

Applications in Research

SIN-1A is extensively used in research to study the role of nitric oxide in various physiological and pathological processes. It is particularly useful in cardiovascular research, where NO is known to play a critical role in vasodilation and blood pressure regulation. Additionally, SIN-1A is used to investigate the effects of NO in the nervous system, immune response, and cellular signaling pathways.

Safety and Handling

As with many chemical compounds, proper safety precautions should be taken when handling SIN-1A. It should be stored in a cool, dry place, and protective equipment such as gloves and goggles should be worn to prevent exposure. In case of contact with skin or eyes, the affected area should be rinsed thoroughly with water.

Also see

• Nitric oxide
• Sydnonimine
• Peroxynitrite
• Vasodilation
• Reactive nitrogen species