TAS2R12

TAS2R12 is a protein that in humans is encoded by the TAS2R12 gene. It is a member of the bitter taste receptor family, which is a group of G protein-coupled receptors. These receptors are specifically located on the taste buds in the mouth and are responsible for the perception of bitter taste.

Function

The TAS2R12 receptor is believed to function in the detection and perception of bitter compounds. It is one of approximately 25 different TAS2R genes in the human genome that encode bitter taste receptors. The specific function of TAS2R12 in taste perception is not fully understood, but it is thought to play a role in the detection of a wide range of bitter compounds.

Structure

Like other G protein-coupled receptors, TAS2R12 is a transmembrane protein. It has seven transmembrane domains and is coupled to a G protein, which is activated when a bitter compound binds to the receptor. The activation of the G protein then triggers a series of biochemical reactions that result in the perception of a bitter taste.

Clinical significance

Mutations in the TAS2R12 gene have been associated with variations in the perception of bitter taste. Some individuals with certain TAS2R12 gene mutations may be more sensitive to certain bitter compounds, while others may be less sensitive. This variation in bitter taste perception can have implications for dietary choices and nutrition.

See also

• Taste receptor
• G protein-coupled receptor
• TAS2R genes