TRIM31

Protein TRIM31 PDB 2YSJ

TRIM31

TRIM31 is a gene that encodes a protein belonging to the tripartite motif (TRIM) family. This protein is involved in various cellular processes, including immune response and antiviral defense mechanisms.

Function

TRIM31 plays a crucial role in regulating the immune response by modulating the activity of certain signaling pathways. It has been shown to interact with components of the innate immune system, such as interferon regulatory factors (IRFs) and NF-κB.

Structure

The TRIM31 protein consists of several domains, including a RING finger domain, a B-box domain, and a coiled-coil domain. These domains are essential for its function in mediating protein-protein interactions and ubiquitination processes.

Role in Disease

Mutations in the TRIM31 gene have been associated with certain autoimmune disorders and inflammatory conditions. Dysregulation of TRIM31 expression can lead to aberrant immune responses and contribute to the pathogenesis of these diseases.

Interactions

TRIM31 has been found to interact with various proteins involved in immune signaling pathways, such as IRF3 and NF-κB. These interactions are crucial for the proper functioning of the immune system and the defense against viral infections.

Clinical Significance

Understanding the role of TRIM31 in immune regulation and disease pathogenesis may provide insights into potential therapeutic targets for autoimmune disorders and inflammatory diseases. Further research is needed to elucidate the precise mechanisms by which TRIM31 exerts its effects on immune responses.