2-Oxoquazepam

2-Oxoquazepam.svg

2-Oxoquazepam is a benzodiazepine derivative. It is a minor active metabolite of the drug quazepam, which is used primarily for its hypnotic and anxiolytic properties.

Pharmacology

2-Oxoquazepam acts on the central nervous system by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor. This action results in sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant properties.

Metabolism

2-Oxoquazepam is formed as a metabolite of quazepam in the liver. Quazepam is metabolized by the cytochrome P450 enzyme system, particularly by the CYP3A4 isoenzyme. The primary metabolic pathway involves the oxidation of quazepam to 2-oxoquazepam, which retains pharmacological activity.

Clinical Use

While 2-oxoquazepam itself is not marketed as a separate drug, its parent compound, quazepam, is used in the treatment of insomnia and other sleep disorders. The presence of 2-oxoquazepam contributes to the overall pharmacological effects of quazepam.

Side Effects

The side effects of 2-oxoquazepam are similar to those of other benzodiazepines and may include drowsiness, dizziness, fatigue, muscle weakness, and cognitive impairment. Long-term use can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.

Legal Status

The legal status of 2-oxoquazepam is not distinct from that of quazepam. Quazepam is classified as a Schedule IV controlled substance under the Controlled Substances Act in the United States, indicating it has a lower potential for abuse and dependence compared to Schedule I, II, or III substances.

See Also

• Benzodiazepine
• Quazepam
• GABA_A receptor
• Cytochrome P450

References

This benzodiazepine-related article is a stub. You can help WikiMD by expanding it.