2-Thiouracil

Thiouracil_Structural_Formula.V2.svg

2-Thiouracil is a chemical compound that belongs to the class of thiouracils. It is a derivative of uracil, where the oxygen atom at the second position is replaced by a sulfur atom. This compound is of interest in the field of biochemistry and pharmacology due to its potential biological activities.

Chemical Properties

2-Thiouracil has the molecular formula C₄H₄N₂OS and a molar mass of 128.15 g/mol. It appears as a crystalline solid and has a melting point of approximately 320°C, at which it decomposes.

Biological Activity

2-Thiouracil is known to exhibit various biological activities. It has been studied for its potential use as an antithyroid agent, which can inhibit the synthesis of thyroid hormones. This makes it relevant in the treatment of conditions such as hyperthyroidism.

Synthesis

The synthesis of 2-thiouracil can be achieved through several chemical reactions, typically involving the introduction of a sulfur atom into the uracil structure. One common method involves the reaction of thiourea with malonic acid derivatives under specific conditions.

Applications

2-Thiouracil has applications in both medical research and pharmaceuticals. It is used in the study of thyroid function and in the development of drugs that can manage thyroid-related disorders. Additionally, it serves as a tool in biochemical research to understand the role of sulfur-containing nucleobases in RNA and DNA.

Safety and Handling

As with many chemical compounds, proper safety measures should be taken when handling 2-thiouracil. It should be stored in a cool, dry place and handled with appropriate protective equipment to avoid inhalation, ingestion, or skin contact.

See Also

• Uracil
• Thyroid hormone
• Hyperthyroidism
• Antithyroid agent

References

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