3,5-Lutidine

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3,5-Lutidine

3,5-Lutidine is a chemical compound that belongs to the family of pyridines, which are heterocyclic aromatic organic compounds. Its chemical formula is C7H9N, indicating that it consists of seven carbon atoms, nine hydrogen atoms, and one nitrogen atom. 3,5-Lutidine is one of the several dimethylpyridine isomers, distinguished by the positions of the methyl groups attached to the pyridine ring. In this case, the methyl groups are located at the 3rd and 5th positions of the ring.

Properties[edit | edit source]

3,5-Lutidine is a colorless liquid at room temperature, with a characteristic odor. It is less dense than water and is slightly soluble in water, but it is more soluble in organic solvents such as ethanol and diethyl ether. This compound exhibits basic properties due to the presence of the nitrogen atom in the pyridine ring, which can donate a pair of electrons.

Synthesis[edit | edit source]

The synthesis of 3,5-Lutidine typically involves the methylation of pyridine or its derivatives. One common method is the reaction of pyridine with formaldehyde and acetaldehyde in the presence of a base, which leads to the formation of various dimethylpyridine isomers, including 3,5-Lutidine.

Applications[edit | edit source]

3,5-Lutidine finds applications in the chemical industry as a starting material or intermediate in the synthesis of other chemical compounds. It is used in the manufacture of agrochemicals, pharmaceuticals, and dyes. Due to its basic properties, 3,5-Lutidine is also employed as a catalyst and a solvent in organic synthesis reactions.

Safety[edit | edit source]

Like many organic solvents, 3,5-Lutidine is flammable and should be handled with care. It can cause irritation to the skin, eyes, and respiratory system upon exposure. Proper safety measures, including the use of personal protective equipment and adequate ventilation, are essential when working with this compound.

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Contributors: Prab R. Tumpati, MD