4-Fluoromethamphetamine

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4-FMA.svg

4-Fluoromethamphetamine (4-FMA) is a synthetic stimulant of the substituted amphetamine class. It is structurally related to methamphetamine and 4-fluoroamphetamine (4-FA), and it acts as a releasing agent of monoamines, including dopamine, serotonin, and norepinephrine.

Chemical Properties[edit | edit source]

4-Fluoromethamphetamine is chemically known as 1-(4-fluorophenyl)-N-methylpropan-2-amine. It has a molecular formula of C10H14FN and a molecular weight of 167.23 g/mol. The presence of a fluorine atom at the para position on the phenyl ring distinguishes it from methamphetamine.

Pharmacology[edit | edit source]

4-FMA functions primarily as a monoamine releasing agent, which means it promotes the release of monoamines such as dopamine, serotonin, and norepinephrine from their storage sites in the presynaptic neuron into the synaptic cleft. This action results in increased concentrations of these neurotransmitters in the brain, leading to stimulant and empathogenic effects.

Effects[edit | edit source]

The effects of 4-FMA are similar to those of other substituted amphetamines, including increased energy, euphoria, enhanced focus, and sociability. However, due to its structural similarity to both methamphetamine and 4-FA, it may also carry risks of neurotoxicity and cardiovascular strain.

Legal Status[edit | edit source]

The legal status of 4-FMA varies by country. In some jurisdictions, it may be classified as a controlled substance due to its structural similarity to other regulated amphetamines. Users should be aware of the legal implications of possessing or distributing 4-FMA in their respective regions.

Safety and Toxicity[edit | edit source]

There is limited research on the safety and toxicity of 4-FMA. As with other synthetic stimulants, potential risks include neurotoxicity, cardiotoxicity, and the potential for abuse and dependence. Users should exercise caution and be aware of the potential for adverse effects.

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]


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Contributors: Prab R. Tumpati, MD