5α-Androst-2-ene-17-one

5alpha-androst-2-ene-17-one.svg

5α-Androst-2-ene-17-one is a chemical compound that belongs to the class of androgens, which are steroid hormones that play a key role in the development and maintenance of male characteristics. This compound is a derivative of androstane and is structurally related to other androgens such as testosterone and dihydrotestosterone (DHT).

Chemical Structure

The chemical structure of 5α-Androst-2-ene-17-one includes a cyclopentanoperhydrophenanthrene ring system, which is characteristic of steroids. The compound has a double bond between the second and third carbon atoms (2-ene) and a ketone group at the 17th carbon position (17-one).

Biological Role

As an androgen, 5α-Androst-2-ene-17-one is involved in the regulation of male reproductive functions and the development of secondary sexual characteristics. It exerts its effects by binding to androgen receptors, which then modulate the expression of specific genes.

Synthesis and Metabolism

5α-Androst-2-ene-17-one can be synthesized from cholesterol through a series of enzymatic reactions. It is metabolized in the body by enzymes such as 5α-reductase, which converts it into more potent androgens like dihydrotestosterone.

Applications

This compound is studied for its potential applications in medicine, particularly in the treatment of conditions related to androgen deficiency. It may also be used in research to understand the mechanisms of androgen action and metabolism.

See Also

• Androgen
• Steroid hormone
• Testosterone
• Dihydrotestosterone
• Androgen receptor

References

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian