9,11-Dehydrocortexolone 17α-butyrate

9,11-Dehydrocortexolone_17α-butyrate.svg

9,11-Dehydrocortexolone 17α-butyrate is a synthetic corticosteroid and a derivative of cortexolone. It is primarily used in the treatment of various skin conditions due to its potent anti-inflammatory properties.

Chemical Structure and Properties

9,11-Dehydrocortexolone 17α-butyrate is a steroid with a specific chemical structure that includes a butyrate ester at the 17α position. This modification enhances its lipophilicity, allowing for better skin penetration and prolonged action.

Mechanism of Action

As a corticosteroid, 9,11-Dehydrocortexolone 17α-butyrate works by binding to glucocorticoid receptors in the skin. This binding inhibits the release of pro-inflammatory cytokines and mediators, reducing inflammation, itching, and redness associated with various dermatological conditions.

Clinical Uses

9,11-Dehydrocortexolone 17α-butyrate is used in the management of:

• Eczema
• Psoriasis
• Dermatitis
• Other inflammatory skin disorders

Side Effects

Common side effects of 9,11-Dehydrocortexolone 17α-butyrate include:

• Skin atrophy
• Striae
• Telangiectasia
• Hypopigmentation

Dosage and Administration

The dosage and administration of 9,11-Dehydrocortexolone 17α-butyrate depend on the severity of the condition being treated. It is typically applied topically to the affected area once or twice daily.

Precautions

Patients using 9,11-Dehydrocortexolone 17α-butyrate should be monitored for signs of adrenal suppression, especially if used over large surface areas or for prolonged periods.

See Also

• Corticosteroid
• Cortexolone
• Glucocorticoid receptor
• Inflammation

References

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