Belnacasan

Belnacasan is a pharmaceutical drug that acts as an inhibitor of the caspase-1 enzyme. It is primarily used in the treatment of auto-inflammatory diseases and conditions characterized by excessive inflammation.

Mechanism of Action

Belnacasan works by inhibiting the activity of caspase-1, an enzyme that plays a crucial role in the inflammatory response. Caspase-1 is responsible for the activation of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). By inhibiting caspase-1, belnacasan reduces the production of these cytokines, thereby decreasing inflammation.

Clinical Uses

Belnacasan is used in the treatment of various auto-inflammatory diseases, including:

• Cryopyrin-associated periodic syndromes (CAPS)
• Familial Mediterranean fever (FMF)
• Gout

Side Effects

Common side effects of belnacasan include:

• Gastrointestinal disturbances
• Headache
• Fatigue

Research and Development

Belnacasan is currently under investigation for its potential use in treating other inflammatory conditions, such as rheumatoid arthritis and inflammatory bowel disease (IBD).

See Also

• Caspase inhibitors
• Auto-inflammatory diseases
• Interleukin-1β
• Interleukin-18

External Links

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