Benzbromarone

Benzbromarone.svg

Benzbromarone is a uricosuric medication primarily used in the treatment of gout and hyperuricemia. It works by increasing the excretion of uric acid in the urine, thereby lowering the levels of uric acid in the blood.

Mechanism of Action

Benzbromarone inhibits the reabsorption of uric acid in the proximal tubule of the kidney. This action is achieved by blocking the URAT1 transporter, which is responsible for the reabsorption of uric acid from the urine back into the blood. By inhibiting this transporter, benzbromarone increases the excretion of uric acid, reducing its concentration in the blood and helping to prevent the formation of uric acid crystals in the joints.

Indications

Benzbromarone is indicated for the treatment of:

• Gout
• Hyperuricemia

Dosage and Administration

The dosage of benzbromarone varies depending on the severity of the condition and the patient's response to the medication. It is typically administered orally, with doses ranging from 50 mg to 200 mg per day. The medication should be taken with food to minimize gastrointestinal side effects.

Side Effects

Common side effects of benzbromarone include:

• Gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea)
• Rash
• Liver enzyme abnormalities

Serious side effects, although rare, may include:

• Hepatotoxicity
• Severe allergic reactions

Contraindications

Benzbromarone is contraindicated in patients with:

• Severe liver disease
• Kidney stones
• Hypersensitivity to benzbromarone or any of its components

Drug Interactions

Benzbromarone may interact with other medications, including:

• Warfarin: Increased risk of bleeding
• Azathioprine: Increased risk of toxicity
• Other uricosuric agents: Potential additive effects

History

Benzbromarone was first introduced in the 1970s and has been used in various countries for the management of gout and hyperuricemia. However, its use has been limited in some regions due to concerns about hepatotoxicity.

See Also

• Gout
• Hyperuricemia
• Uricosuric
• URAT1

External Links

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