CDH1
CDH1 (also known as E-cadherin) is a gene that provides instructions for making a protein that is involved in cell adhesion. This protein is found in epithelial tissues, which line the surfaces and cavities of the body. The CDH1 gene is located on the long (q) arm of chromosome 16 at position 22.1.
Function[edit | edit source]
The CDH1 gene provides instructions for making a protein called E-cadherin. E-cadherin is a type of protein known as a cell adhesion molecule, which helps cells stick together and also helps cells to interact and communicate with each other. E-cadherin is found in cells throughout the body, particularly in epithelial cells, which line the surfaces and cavities of the body.
Clinical significance[edit | edit source]
Mutations in the CDH1 gene are associated with Hereditary Diffuse Gastric Cancer (HDGC), a rare form of stomach cancer that is inherited in an autosomal dominant manner. Mutations in this gene are also associated with lobular breast cancer, cleft lip and/or cleft palate, and invasive lobular carcinoma.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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