CGP-35348

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CGP-35348 structure.png

CGP-35348 is a compound that acts as a GABA B receptor antagonist. It is used in scientific research to investigate the role of GABA B receptors in various physiological and neurological processes.

Mechanism of Action

CGP-35348 works by inhibiting the action of gamma-Aminobutyric acid (GABA) at the GABA B receptor. This receptor is a G-protein coupled receptor that mediates slow and prolonged inhibitory signals in the central nervous system. By blocking this receptor, CGP-35348 can modulate neurotransmission and affect various neurological and psychiatric conditions.

Research Applications

CGP-35348 has been used in various preclinical studies to understand the role of GABA B receptors in anxiety, depression, epilepsy, and pain. It has also been investigated for its potential effects on cognition and memory.

Pharmacokinetics

The pharmacokinetics of CGP-35348 involve its absorption, distribution, metabolism, and excretion. Detailed studies on its bioavailability, half-life, and metabolic pathways are essential for understanding its potential therapeutic applications.

Safety and Toxicology

As with any pharmacological agent, the safety and toxicology profile of CGP-35348 is crucial. Studies typically focus on its LD50, potential side effects, and long-term impact on organ systems.

See Also

• GABA B receptor
• GABA
• Neurotransmission
• Pharmacology

References

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