Clorexolone

Clorexolone is a synthetic glucocorticoid and corticosteroid medication. It is primarily used for its anti-inflammatory and immunosuppressive properties. Clorexolone is part of a class of drugs known as corticosteroids, which are used to treat a variety of conditions, including allergic reactions, asthma, autoimmune diseases, and inflammatory disorders.

Pharmacology

Clorexolone works by mimicking the effects of cortisol, a hormone produced by the adrenal glands. It binds to glucocorticoid receptors in the body, leading to a reduction in the production of inflammatory mediators such as cytokines and prostaglandins. This action helps to decrease inflammation and modulate the immune response.

Medical Uses

Clorexolone is used in the treatment of several conditions, including:

• Asthma
• Rheumatoid arthritis
• Lupus erythematosus
• Inflammatory bowel disease
• Allergic reactions

Side Effects

Like other corticosteroids, Clorexolone can cause a range of side effects, particularly with long-term use. Common side effects include:

• Weight gain
• Hypertension
• Osteoporosis
• Hyperglycemia
• Increased risk of infection

Contraindications

Clorexolone should not be used in individuals with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with systemic fungal infections and those receiving live or live-attenuated vaccines.

Dosage

The dosage of Clorexolone varies depending on the condition being treated and the patient's response to therapy. It is important to follow the prescribing physician's instructions and not to discontinue the medication abruptly, as this can lead to adrenal insufficiency.

See Also

• Glucocorticoid
• Corticosteroid
• Anti-inflammatory
• Immunosuppressive drug

External Links

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