Dazoxiben

Dazoxiben.svg

Dazoxiben is a thromboxane synthase inhibitor that has been studied for its potential use in treating various cardiovascular diseases. It works by inhibiting the synthesis of thromboxane, a compound that promotes platelet aggregation and vasoconstriction.

Mechanism of Action

Dazoxiben inhibits the enzyme thromboxane-A synthase, which is responsible for converting prostaglandin H2 into thromboxane A2. By blocking this conversion, dazoxiben reduces the levels of thromboxane A2, leading to decreased platelet aggregation and vasodilation. This mechanism makes it a potential therapeutic agent for conditions where platelet aggregation and vasoconstriction are problematic, such as myocardial infarction and stroke.

Clinical Applications

Dazoxiben has been investigated for its use in various cardiovascular conditions, including:

• Myocardial infarction
• Stroke
• Peripheral artery disease
• Thrombosis

Side Effects

The use of dazoxiben may be associated with several side effects, including:

• Gastrointestinal disturbances
• Headache
• Dizziness
• Hypotension

Research and Development

While dazoxiben showed promise in early studies, its development has been limited due to the emergence of more effective and safer alternatives. Research continues to explore its potential applications and long-term effects.

See Also

• Thromboxane
• Platelet aggregation
• Cardiovascular disease
• Thrombosis
• Vasoconstriction

External Links

-

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian