Estradiol benzoate butyrate

Estradiol_butyrate_benzoate.svg

Estradiol benzoate butyrate is a synthetic estrogen and an estrogen ester, specifically the C17β benzoate and butyrate diester of estradiol. It is used in hormone replacement therapy and for other medical purposes.

Chemical Structure and Properties

Estradiol benzoate butyrate is a white to off-white crystalline powder. It is practically insoluble in water but soluble in organic solvents such as ethanol and chloroform. The chemical formula of estradiol benzoate butyrate is C₂₈H₃₆O₄.

Mechanism of Action

As an estrogen, estradiol benzoate butyrate binds to and activates the estrogen receptors in various tissues. This activation leads to the modulation of the expression of certain genes, resulting in the typical effects of estrogen, such as the development and maintenance of female secondary sexual characteristics and the regulation of the menstrual cycle.

Medical Uses

Estradiol benzoate butyrate is used in hormone replacement therapy (HRT) for the treatment of symptoms associated with menopause, such as hot flashes, vaginal atrophy, and osteoporosis. It is also used in the treatment of hypoestrogenism due to hypogonadism, ovarian failure, or oophorectomy.

Pharmacokinetics

After administration, estradiol benzoate butyrate is hydrolyzed to estradiol, which is the active form of the hormone. The pharmacokinetics of estradiol benzoate butyrate are similar to those of other estradiol esters, with a prolonged duration of action compared to estradiol itself.

Side Effects

Common side effects of estradiol benzoate butyrate include nausea, headache, breast tenderness, and fluid retention. Long-term use of estrogens has been associated with an increased risk of endometrial cancer, breast cancer, and cardiovascular disease.

See Also

• Estradiol
• Estrogen
• Hormone replacement therapy
• Menopause

External Links

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