Estradiol hexahydrobenzoate

Estradiol_hexahydrobenzoate.svg

Estradiol hexahydrobenzoate (EHHB) is a synthetic, steroidal estrogen and an estrogen ester. It is the C17β hexahydrobenzoate (cyclohexanecarboxylate) ester of estradiol. EHHB is used in hormone replacement therapy (HRT) for menopausal symptoms and in hormonal contraception.

Chemical Structure

Estradiol hexahydrobenzoate is a derivative of estradiol, which is a naturally occurring estrogen in the human body. The chemical structure of EHHB includes the addition of a hexahydrobenzoate ester at the C17β position of the estradiol molecule. This modification increases the lipophilicity of the molecule, allowing for a slower release and longer duration of action when administered.

Pharmacokinetics

EHHB is administered via intramuscular injection. Once in the body, it is slowly hydrolyzed to release free estradiol, which then exerts its biological effects. The esterification of estradiol with hexahydrobenzoate prolongs its duration of action, reducing the frequency of administration required.

Medical Uses

EHHB is primarily used in hormone replacement therapy for the treatment of menopausal symptoms such as hot flashes, vaginal atrophy, and osteoporosis. It is also used in hormonal contraception in combination with progestins.

Side Effects

The side effects of EHHB are similar to those of other estrogens and may include nausea, breast tenderness, headache, and fluid retention. Long-term use of estrogens has been associated with an increased risk of endometrial cancer, breast cancer, and cardiovascular disease.

See Also

• Estradiol
• Estrogen
• Hormone replacement therapy
• Hormonal contraception

External Links

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