Etofamide

Etofamide is an antiprotozoal medication used primarily in the treatment of amoebiasis. It is a member of the amide class of compounds and works by inhibiting the growth of Entamoeba histolytica, the protozoan responsible for amoebiasis.

Mechanism of Action

Etofamide exerts its antiprotozoal effects by interfering with the DNA synthesis of Entamoeba histolytica. This inhibition prevents the protozoan from replicating and spreading within the host's gastrointestinal tract.

Indications

Etofamide is indicated for the treatment of:

• Amoebiasis
• Giardiasis

Pharmacokinetics

Etofamide is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and excreted primarily through the kidneys.

Side Effects

Common side effects of etofamide include:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain

Contraindications

Etofamide is contraindicated in patients with:

• Known hypersensitivity to etofamide or any of its components
• Severe hepatic impairment

Drug Interactions

Etofamide may interact with other medications, including:

• Metronidazole
• Tinidazole

Dosage

The dosage of etofamide varies depending on the severity of the infection and the patient's overall health. It is important to follow the prescribing physician's instructions carefully.

See Also

• Amoebiasis
• Antiprotozoal
• Entamoeba histolytica

External Links

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