GRIK2
GRIK2 or Glutamate Ionotropic Receptor Kainate Type Subunit 2 is a protein that in humans is encoded by the GRIK2 gene. It is a member of the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.
Function[edit | edit source]
The protein encoded by the GRIK2 gene is a subunit of a kainate glutamate receptor. Glutamate receptors mediate the majority of excitatory neurotransmission in the brain. This receptor may have a role in synaptic plasticity, a process that underlies learning and memory. It is thought to interact with other proteins, like Neto1 and Neto2, to regulate kainate receptor function.
Clinical significance[edit | edit source]
Mutations in the GRIK2 gene have been associated with several neurological disorders, including autism, schizophrenia, and bipolar disorder. Studies have also suggested a potential role in the development and progression of Parkinson's disease.
Structure[edit | edit source]
The GRIK2 protein is a transmembrane protein, meaning it spans the membrane of the cells in which it is expressed. It is composed of several domains, including an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is responsible for binding to glutamate, while the transmembrane domain forms the ion channel.
See also[edit | edit source]
References[edit | edit source]
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD