Ibuproxam

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Ibuproxam is a nonsteroidal anti-inflammatory drug (NSAID) used for its analgesic, antipyretic, and anti-inflammatory properties. It is a derivative of ibuprofen, which is one of the most commonly used NSAIDs.

Pharmacology

Ibuproxam works by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are involved in the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. By reducing the production of prostaglandins, ibuproxam helps to alleviate symptoms associated with inflammatory conditions.

Uses

Ibuproxam is indicated for the treatment of various conditions such as arthritis, musculoskeletal pain, dysmenorrhea, and other inflammatory disorders. It is also used to reduce fever and relieve mild to moderate pain.

Side Effects

Common side effects of ibuproxam include gastrointestinal issues such as nausea, vomiting, diarrhea, and stomach pain. More serious side effects can include gastrointestinal bleeding, ulcers, and kidney damage. Patients are advised to use the medication under medical supervision, especially if they have a history of peptic ulcer disease or renal impairment.

Contraindications

Ibuproxam should not be used in individuals with known hypersensitivity to ibuprofen or other NSAIDs. It is also contraindicated in patients with active gastrointestinal bleeding, severe heart failure, and those who have undergone coronary artery bypass graft surgery.

Interactions

Ibuproxam can interact with other medications such as anticoagulants, antihypertensives, and other NSAIDs. These interactions can increase the risk of adverse effects and reduce the efficacy of the medications.

Dosage

The dosage of ibuproxam varies depending on the condition being treated and the patient's response to the medication. It is important to follow the prescribed dosage and not to exceed the recommended amount to avoid potential side effects.

See also

• Ibuprofen
• Nonsteroidal anti-inflammatory drug
• Cyclooxygenase
• Prostaglandin

References

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