Interferon gamma receptor 1
Interferon gamma receptor 1 (IFNγR1) is a type of protein that in humans is encoded by the IFNGR1 gene. It is a part of the interferon receptor family, specifically for interferon gamma (IFNγ).
Structure[edit | edit source]
IFNγR1 is a transmembrane protein that is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is responsible for binding to IFNγ, while the intracellular domain is involved in signal transduction.
Function[edit | edit source]
IFNγR1 is a critical component of the immune response. It is the receptor for IFNγ, a cytokine that plays a key role in the immune response to infections and cancer. When IFNγ binds to IFNγR1, it triggers a cascade of intracellular events that lead to the activation of immune cells and the production of molecules that help fight off infections and tumors.
Clinical significance[edit | edit source]
Mutations in the IFNGR1 gene can lead to a condition known as Mendelian susceptibility to mycobacterial disease (MSMD). This is a rare genetic disorder that makes individuals more susceptible to certain types of infections, particularly those caused by mycobacteria and some viruses.
See also[edit | edit source]
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External links[edit | edit source]
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD