Interleukin 9 receptor
Interleukin 9 receptor (also known as IL9R) is a type of protein that in humans is encoded by the IL9R gene. It is a member of the interleukin receptor family, which plays a crucial role in the immune system.
Function[edit | edit source]
The IL9R protein is a receptor for interleukin 9 (IL9), a cytokine (a type of signaling molecule) involved in various biological processes. The binding of IL9 to this receptor can lead to the proliferation and survival of certain cell types, including T cells and mast cells. This receptor is also involved in the regulation of immune responses and inflammation.
Structure[edit | edit source]
The IL9R protein is a type of transmembrane protein, meaning it spans the entire cell membrane. It is composed of an extracellular domain, which binds to IL9, a transmembrane domain, and an intracellular domain, which transmits the signal into the cell.
Clinical significance[edit | edit source]
Mutations in the IL9R gene can lead to immunodeficiency conditions, such as X-linked severe combined immunodeficiency (X-SCID). Additionally, overexpression of IL9R has been associated with certain types of cancer, including leukemia and lymphoma.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD