KCNA4

KCNA4 is a gene that encodes the voltage-gated potassium channel subunit Kv1.4. This protein is a member of the potassium channel family, which is a diverse group of ion channels that regulate a variety of cellular processes.

Function

The KCNA4 gene is responsible for the production of a protein that forms a part of the voltage-gated potassium channels. These channels play a crucial role in the electrical activity of cells, particularly in neurons and muscle cells. The Kv1.4 subunit, encoded by the KCNA4 gene, contributes to the channels' ability to open and close in response to changes in the electrical charge across the cell membrane.

Clinical Significance

Mutations in the KCNA4 gene have been associated with certain medical conditions. For instance, some studies suggest a link between KCNA4 mutations and episodic ataxia, a neurological disorder characterized by recurrent episodes of poor coordination and balance. However, more research is needed to confirm these findings and understand the exact role of KCNA4 in disease.

Research

Research on the KCNA4 gene and its encoded protein is ongoing, with scientists seeking to understand their roles in health and disease. This research could potentially lead to new treatments for diseases associated with abnormalities in potassium channel function.

See Also

• Voltage-gated potassium channel
• Episodic ataxia
• Potassium channel

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