KCNK6

KCNK6 is a human gene that encodes for the protein known as Potassium Two Pore Domain Channel Subfamily K Member 6. This protein is a member of the potassium channel family of proteins, which are integral membrane proteins that establish a voltage gradient across the cell membrane.

Function

The KCNK6 protein is a member of the superfamily of potassium channel proteins containing two pore-forming P domains. KCNK6 represents a subfamily of K2P channels that are functionally silent without co-expression of an accessory Beta subunit. The protein encoded by the KCNK6 gene is an outwardly rectifying potassium channel and is thought to play a critical role in the regulation of neuronal excitability.

Clinical Significance

Mutations in the KCNK6 gene have been associated with several diseases, including migraines and epilepsy. Research is ongoing to further understand the role of this gene in human health and disease.

See Also

• Potassium channel
• Beta subunit
• Migraine
• Epilepsy

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