MAP3K15
MAP3K15 (Mitogen-Activated Protein Kinase Kinase Kinase 15) is a protein that in humans is encoded by the MAP3K15 gene. This protein is part of the MAPK/ERK pathway, which is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
Function[edit | edit source]
The MAP3K15 protein is a member of the serine/threonine protein kinase family. This kinase is known to play a critical role in mitotic cell cycle progression and DNA damage response. When activated, it initiates a cascade of phosphorylation events that are crucial for cell cycle progression and prevention of DNA replication errors.
Clinical Significance[edit | edit source]
Alterations in the MAP3K15 gene have been associated with various human diseases, including cancer. In particular, mutations in this gene have been found in a variety of cancers, suggesting that it may act as a tumor suppressor gene. Further research is needed to fully understand the role of MAP3K15 in human disease.
See Also[edit | edit source]
References[edit | edit source]
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