Meralluride
Meralluride is a pharmaceutical drug that belongs to the class of diuretics. It is primarily used in the treatment of conditions that require the removal of excess fluid from the body, such as edema and hypertension.
Mechanism of Action[edit | edit source]
Meralluride works by inhibiting the reabsorption of sodium and chloride ions in the kidneys, which leads to an increase in the excretion of water, sodium, and chloride. This diuretic effect helps to reduce the volume of fluid in the body, thereby lowering blood pressure and reducing swelling.
Uses[edit | edit source]
Meralluride is indicated for the management of:
- Edema associated with congestive heart failure, liver cirrhosis, and renal disease.
- Hypertension.
Side Effects[edit | edit source]
Common side effects of Meralluride include:
- Electrolyte imbalance, such as low levels of potassium and sodium.
- Dehydration.
- Hypotension.
- Dizziness.
- Headache.
Contraindications[edit | edit source]
Meralluride should not be used in patients with:
- Anuria (inability to urinate).
- Severe renal impairment.
- Known hypersensitivity to the drug or its components.
Interactions[edit | edit source]
Meralluride may interact with other medications, including:
- Antihypertensive drugs, which may enhance the blood pressure-lowering effect.
- Nonsteroidal anti-inflammatory drugs (NSAIDs), which may reduce the diuretic effect.
- Lithium, as it may increase the risk of lithium toxicity.
Administration[edit | edit source]
Meralluride is typically administered orally, with the dosage and frequency determined by the treating physician based on the patient's condition and response to therapy.
See Also[edit | edit source]
References[edit | edit source]
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