Muse cell

Muse cells are non-tumorigenic pluripotent stem cells that can self-renew and display the ability to differentiate into endodermal, ectodermal, and mesodermal cells. They were discovered in 2010 by a team of researchers led by Mari Dezawa.

Discovery

The discovery of Muse cells was made by a team of researchers led by Mari Dezawa in 2010. The team was studying mesenchymal stem cells (MSCs) when they noticed a small population of cells that were resistant to stress, such as low oxygen levels or high cell density. These cells were named Muse cells, an acronym for "Multilineage-differentiating Stress-Enduring" cells.

Characteristics

Muse cells are characterized by their ability to self-renew and differentiate into endodermal, ectodermal, and mesenchymal cells. They are also non-tumorigenic, meaning they do not form tumors when transplanted into a host organism. Muse cells express several markers of pluripotency, including SSEA-3, TRA-1-60, and TRA-1-81, and can be found in various tissues, including bone marrow, skin, and adipose tissue.

Potential Applications

Due to their pluripotency and non-tumorigenic nature, Muse cells have potential applications in regenerative medicine. They could be used for cell replacement therapy in a variety of diseases and conditions, including Parkinson's disease, heart disease, and spinal cord injury. However, more research is needed to fully understand the potential of these cells and to develop safe and effective methods for their use in clinical settings.

Research

Research on Muse cells is ongoing, with studies focusing on understanding their biology and exploring their potential use in regenerative medicine. Some studies have shown that Muse cells can contribute to tissue repair and regeneration in animal models of disease. However, more research is needed to confirm these findings and to determine the best methods for isolating, expanding, and delivering Muse cells for therapeutic purposes.

See Also

• Stem cell
• Regenerative medicine
• Cell therapy
• Pluripotency

References

Muse cell Resources
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