Nalbuphine hydrochloride

Nalbuphine Hydrochloride is a semi-synthetic opioid used primarily in the management of moderate to severe pain. It is also used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.

Pharmacology

Nalbuphine Hydrochloride is a potent analgesic. Its analgesic potency is essentially equivalent to that of morphine on a milligram basis. The onset of action occurs within 2 to 3 minutes after intravenous administration, and in less than 15 minutes following subcutaneous or intramuscular injection. The plasma half-life of nalbuphine is approximately 5 hours.

Clinical Uses

Nalbuphine Hydrochloride is indicated for the relief of moderate to severe pain. It can also be used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.

Side Effects

Like other opioids, Nalbuphine Hydrochloride can cause a number of side effects, including nausea, vomiting, dizziness, and sedation. In rare cases, it can cause serious side effects such as respiratory depression and dependence.

Contraindications

Nalbuphine Hydrochloride is contraindicated in patients who are hypersensitive to nalbuphine or to any of the other ingredients in the formulation. It should also be used with caution in patients with impaired respiratory function or with a history of substance abuse.

See Also

• Opioid
• Analgesic
• Morphine

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