Nesfatin-1
Nesfatin-1 is a protein that is encoded by the NUCB2 gene in humans. It is involved in the regulation of appetite and body weight.
Function[edit | edit source]
Nesfatin-1 is a peptide hormone produced in the hypothalamus, a region of the brain that regulates hunger and satiety. It is also found in other tissues, including the stomach and pancreas. Nesfatin-1 suppresses food intake and reduces body weight. It is thought to act by influencing the activity of neurons in the hypothalamus that control appetite.
Role in Disease[edit | edit source]
Alterations in the levels of nesfatin-1 have been associated with several diseases, including obesity, diabetes, and depression. In obesity, levels of nesfatin-1 are often reduced, while in diabetes, they may be increased. The role of nesfatin-1 in depression is less clear, but it may be involved in the regulation of mood and stress responses.
Research[edit | edit source]
Research on nesfatin-1 is ongoing, with studies investigating its potential as a target for the treatment of obesity and other metabolic disorders. Some studies have also suggested that nesfatin-1 may have anti-inflammatory effects, which could be beneficial in the treatment of diseases such as rheumatoid arthritis and inflammatory bowel disease.
See Also[edit | edit source]
References[edit | edit source]
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