Nitromethaqualone

Nitromethaqualone.svg

Nitromethaqualone is a pharmaceutical drug that belongs to the quinazolinone class of sedative and hypnotic medications. It is a derivative of methaqualone, a well-known sedative and hypnotic drug that was widely used in the mid-20th century.

Chemical Structure and Properties

Nitromethaqualone is chemically related to methaqualone, with the addition of a nitro group to its molecular structure. This modification results in differences in its pharmacological properties compared to methaqualone. The chemical formula of nitromethaqualone is C16H14N2O3.

Pharmacology

Nitromethaqualone acts on the central nervous system (CNS) to produce its sedative and hypnotic effects. It is believed to work by enhancing the activity of the gamma-aminobutyric acid (GABA) neurotransmitter, which is the primary inhibitory neurotransmitter in the CNS. This action results in a calming effect on the brain and body, making it useful for the treatment of insomnia and anxiety.

Medical Uses

Nitromethaqualone has been used in the past for its sedative and hypnotic properties. It was prescribed for the treatment of insomnia, anxiety, and other conditions requiring CNS depression. However, due to its potential for abuse and the development of safer alternatives, its use has declined significantly.

Side Effects

The side effects of nitromethaqualone are similar to those of other sedative-hypnotic drugs. Common side effects include drowsiness, dizziness, headache, and nausea. In higher doses, it can cause more severe effects such as respiratory depression, hypotension, and coma.

Abuse and Dependence

Like its parent compound methaqualone, nitromethaqualone has a high potential for abuse and dependence. It can produce feelings of euphoria and relaxation, which can lead to recreational use and addiction. Long-term use can result in physical and psychological dependence, and withdrawal symptoms can be severe.

Legal Status

Due to its potential for abuse and the availability of safer alternatives, nitromethaqualone is a controlled substance in many countries. Its production, distribution, and use are strictly regulated to prevent misuse and addiction.

See Also

• Methaqualone
• Sedative
• Hypnotic
• Central nervous system
• Gamma-aminobutyric acid

External Links

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