Nitroxazepine

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Nitroxazepine is a tricyclic antidepressant (TCA) that is primarily used in the treatment of depression. It belongs to the class of dibenzazepine compounds and is known for its efficacy in alleviating symptoms of major depressive disorder.

Pharmacology

Nitroxazepine works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine, thereby increasing their levels in the synaptic cleft and enhancing neurotransmission. This mechanism of action is similar to other tricyclic antidepressants like amitriptyline and imipramine.

Indications

Nitroxazepine is indicated for the treatment of:

• Major depressive disorder
• Anxiety disorders
• Chronic pain (off-label use)

Side Effects

Common side effects of nitroxazepine include:

• Dry mouth
• Constipation
• Drowsiness
• Weight gain
• Blurred vision

Serious side effects may include:

• Cardiac arrhythmias
• Seizures
• Orthostatic hypotension

Contraindications

Nitroxazepine is contraindicated in patients with:

• Hypersensitivity to tricyclic antidepressants
• Recent myocardial infarction
• Severe liver disease

Interactions

Nitroxazepine may interact with:

• Monoamine oxidase inhibitors (MAOIs)
• Selective serotonin reuptake inhibitors (SSRIs)
• Anticholinergic drugs
• Alcohol

Dosage

The dosage of nitroxazepine varies depending on the condition being treated and the patient's response to the medication. It is typically started at a low dose and gradually increased to minimize side effects.

History

Nitroxazepine was developed in the late 20th century and has been used in various countries for the treatment of depression and related disorders. It is less commonly prescribed today due to the availability of newer antidepressants with more favorable side effect profiles.

See Also

• Tricyclic antidepressant
• Serotonin
• Norepinephrine
• Depression
• Anxiety disorder

External Links

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