Paraoxon

Paraoxon_structure.svg

Paraoxon is a highly toxic organophosphate compound that is used as a pesticide. It is the active metabolite of parathion, which is converted to paraoxon in the liver. Paraoxon is known for its potent inhibition of the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine in the nervous system and causing severe neurological effects.

Chemical Structure and Properties

Paraoxon has the chemical formula C10H14NO6P and a molecular weight of 275.20 g/mol. It is an organophosphate ester and is structurally related to other organophosphates such as sarin and malathion. The compound is typically a colorless to yellow-brown liquid with a faint odor.

Mechanism of Action

Paraoxon exerts its toxic effects primarily through the inhibition of acetylcholinesterase, an enzyme responsible for breaking down acetylcholine in the synaptic cleft. By inhibiting this enzyme, paraoxon causes an accumulation of acetylcholine, leading to continuous stimulation of muscarinic and nicotinic receptors. This results in a range of symptoms including muscle twitching, respiratory distress, convulsions, and potentially death.

Toxicity and Symptoms

Exposure to paraoxon can occur through inhalation, ingestion, or dermal contact. Symptoms of paraoxon poisoning include:

• Miosis (constriction of the pupils)
• Excessive salivation
• Sweating
• Muscle twitching and weakness
• Respiratory distress
• Convulsions
• Coma

Treatment

The primary treatment for paraoxon poisoning involves the administration of atropine, an antimuscarinic agent, and pralidoxime, which reactivates acetylcholinesterase. Supportive care, including respiratory support, may also be necessary.

Environmental Impact

Paraoxon, like other organophosphates, can have significant environmental impacts. It is highly toxic to a wide range of organisms, including insects, birds, and aquatic life. The use of paraoxon and related compounds is regulated in many countries to minimize environmental contamination and human exposure.

Regulation and Safety

Due to its high toxicity, the use of paraoxon is strictly regulated. Safety measures include the use of personal protective equipment (PPE) for individuals handling the compound and strict guidelines for its application in agricultural settings.

See Also

• Parathion
• Acetylcholinesterase
• Organophosphate poisoning
• Atropine
• Pralidoxime

References

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