Pyroglutamylated RFamide peptide receptor
Pyroglutamylated RFamide peptide receptor (QRFPR), also known as G-protein coupled receptor 103 (GPR103), is a protein that in humans is encoded by the QRFPR gene. It is a member of the G protein-coupled receptor family, a large group of proteins that play a role in many different physiological functions.
Function[edit | edit source]
The QRFPR gene encodes a protein that is a member of the rhodopsin family of G protein-coupled receptors. These receptors are integral membrane proteins that contain seven transmembrane domains and are involved in many different physiological functions. The encoded protein is a receptor for pyroglutamylated RFamide peptide (QRFP), and functions in appetite regulation.
Clinical significance[edit | edit source]
Alterations in the QRFPR gene have been associated with obesity and eating disorders. Studies have shown that QRFP and its receptor may play a role in the regulation of energy homeostasis and obesity.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- Human QRFPR gene details page in the National Center for Biotechnology Information (NCBI) website.
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