Remicade
Remicade (also known as Infliximab) is a chimeric monoclonal antibody biologic drug that works against tumor necrosis factor alpha (TNF-α) and is used to treat autoimmune diseases. It is produced by Janssen Biotech, which is owned by Johnson & Johnson.
Medical Uses[edit | edit source]
Remicade is used for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. It works by binding to TNF-α. TNF-α is a chemical messenger in the immune system and is also a key factor in the inflammatory process of autoimmune diseases.
Side Effects[edit | edit source]
Common side effects include infections (such as tuberculosis, sepsis, and fungal infections), infusion reactions, headache, stomach pain, and nausea. Serious side effects may include heart failure, a higher rate of serious infections, and an increased risk of cancer.
Pharmacology[edit | edit source]
Infliximab is a chimeric monoclonal antibody. It is composed of human constant and murine variable regions. Infliximab binds specifically to TNF-α and blocks its interaction with the p55 and p75 cell surface TNF receptors.
History[edit | edit source]
Remicade was approved for medical use in the United States in 1998, and in the European Union in 1999. It was the first TNF-α blocker to be approved.
See Also[edit | edit source]
Remicade Resources | ||
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